IL-12 and related cytokines: Function and regulatory implications in Candida albicans Infection

Ashman, Robert B., Vijayan, Dipti and Wells, Christine A. (2011) IL-12 and related cytokines: Function and regulatory implications in Candida albicans Infection. Clinical and Developmental Immunology, 2011 686597-1-686597-9. doi:10.1155/2011/686597

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Author Ashman, Robert B.
Vijayan, Dipti
Wells, Christine A.
Title IL-12 and related cytokines: Function and regulatory implications in Candida albicans Infection
Formatted title
IL-12 and related cytokines: Function and regulatory implications in Candida albicans infection
Journal name Clinical and Developmental Immunology   Check publisher's open access policy
ISSN 1740-2522
1740-2530
Publication date 2011-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2011/686597
Open Access Status File (Publisher version)
Volume 2011
Start page 686597-1
End page 686597-9
Total pages 9
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Collection year 2012
Language eng
Formatted abstract
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
Keyword Tumor-necrosis-factor
Acute systemic candidiasis
Host-defense
Murine candidiasis
Oral candidiasis
Immune-responses
IFN-gamma production
Mucosal candidiasis
IFN-γ production
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 30 Jan 2011, 10:06:08 EST