9-(5‘-Deoxy-5’-thio-β-d-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer: The first natural occurrence of a nucleoside disulfide

Peng, Chongsheng, Gunaherath, G. M. Kamal B., Piggott, Andrew M., Khalil, Zeinab, Conte, Melissa and Capon, Robert J. (2010) 9-(5‘-Deoxy-5’-thio-β-d-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer: The first natural occurrence of a nucleoside disulfide. Australian Journal of Chemistry, 63 6: 873-876. doi:10.1071/CH09645


Author Peng, Chongsheng
Gunaherath, G. M. Kamal B.
Piggott, Andrew M.
Khalil, Zeinab
Conte, Melissa
Capon, Robert J.
Title 9-(5‘-Deoxy-5’-thio-β-d-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer: The first natural occurrence of a nucleoside disulfide
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 0004-9425
Publication date 2010-06
Sub-type Article (original research)
DOI 10.1071/CH09645
Volume 63
Issue 6
Start page 873
End page 876
Total pages 4
Place of publication Collingwood, Vic., Australia
Publisher CSIRO (Commonwealth Scientific and Industrial Research Organisation)
Collection year 2011
Language eng
Formatted abstract
Chemical fractionation of a southern Australian marine sponge, Trachycladus laevispirulifer, yielded 9-(5′-deoxy-5′-thio-β-d-xylofuranosyl)adenine disulfide as the first recorded natural occurrence of a nucleoside disulfide, and only the second of a xylo-nucleoside. Structure elucidation of the disulfide was achieved by detailed spectroscopic analysis and comparison to synthetic model compounds. The antibacterial, antifungal, and anticancer properties of the disulfide are documented and the literature surrounding natural and synthetic thionucleosides is reviewed.

Keyword Naturally-occurring analog
Doris-Verrucosa
Methylthioadenosine
Identification
Adenosine
Kinases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published: 11 June 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 28 Jan 2011, 15:19:13 EST by Susan Allen on behalf of Institute for Molecular Bioscience