The role of basic science in evidence-based medicine

La Caze, Adam (2011) The role of basic science in evidence-based medicine. Biology and Philosophy, 26 1: 81-98. doi:10.1007/s10539-010-9231-5

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Author La Caze, Adam
Title The role of basic science in evidence-based medicine
Journal name Biology and Philosophy   Check publisher's open access policy
ISSN 0169-3867
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1007/s10539-010-9231-5
Open Access Status
Volume 26
Issue 1
Start page 81
End page 98
Total pages 18
Place of publication Dordrecht, The Netherlands
Publisher Springer Netherlands
Collection year 2011
Language eng
Abstract Proponents of Evidence-based medicine (EBM) do not provide a clear role for basic science in therapeutic decision making. Of what they do say about basic science, most of it is negative. Basic science resides on the lower tiers of EBM's hierarchy of evidence. Therapeutic decisions, according to proponents of EBM, should be informed by evidence from randomised studies (and systematic reviews of randomised studies) rather than basic science. A framework of models explicates the links between the mechanisms of basic science, experimental inquiry, and observed data. Relying on the framework of models I show that basic science often plays a role not only in specifying experiments, but also analysing and interpreting the data that is provided. Further, and contradicting what is implied in EBM's hierarchy of evidence, appeals to basic science are often required to apply clinical research to therapeutic questions. © 2010 Springer Science+Business Media B.V.
Keyword Evidence-based medicine
Basic medical science
Clinical decisions
Randomised controlled trials
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 12 September 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 23 Jan 2011, 00:07:25 EST