SerpinB2 deficiency modulates Th1/Th2 responses after schistosome infection

Schroder, W. A., Gardner, J., Le, T. T., Duke, M., Burke, M. L., Jones, M. K., McManus, D. P. and Suhrbier, A. (2010) SerpinB2 deficiency modulates Th1/Th2 responses after schistosome infection. Parasite Immunology, 32 11-12: 764-768. doi:10.1111/j.1365-3024.2010.01241.x

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Author Schroder, W. A.
Gardner, J.
Le, T. T.
Duke, M.
Burke, M. L.
Jones, M. K.
McManus, D. P.
Suhrbier, A.
Title SerpinB2 deficiency modulates Th1/Th2 responses after schistosome infection
Journal name Parasite Immunology   Check publisher's open access policy
ISSN 0141-9838
1365-3024
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1111/j.1365-3024.2010.01241.x
Volume 32
Issue 11-12
Start page 764
End page 768
Total pages 5
Place of publication Oxford, U.K.
Publisher Blackwell Scientific Publications
Collection year 2011
Language eng
Formatted abstract
SerpinB2, also known as plasminogen activator inhibitor type-2, is a major product of macrophages and is upregulated during many infections. Although SerpinB2 inhibits urokinase plasminogen activator in vitro, evidence that this represents its physiological role in vivo is not compelling. We have recently shown that SerpinB2−/− mice generate enhanced Th1 responses after immunization with a Th1 immunogen. Herein, we show that Schistosoma japonicum granulomas induced liver SerpinB2 mRNA expression by >600-fold in wild-type mice. In SerpinB2−/− mice, worm and egg burden, and granuloma number and volume were unaffected. However, granulomas in these mice were associated with reduced fibrosis (as determined by Sirius red staining and image analysis) and increased iNOS, IL-6, IL-10 and TNFα and decreased Arg 1 and IL-13 mRNA expression. SerpinB2−/− mice immunized with soluble egg antigen (SEA) also showed reduced levels of SEA-specific IgG1. SerpinB2 deficiency thus promoted certain Th1 and reduced certain Th2 responses in response to this Th2 immunogen.
© 2010 Blackwell Publishing Ltd.
Keyword Fibrosis
Immunoregulation
Schistosoma japonicum
SerpinB2
Th1/Th2
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Veterinary Science Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 21 Jan 2011, 17:22:47 EST by Dr Malcolm Jones on behalf of School of Veterinary Science