Prototypes for bone implant scaffolds designed via topology optimization and manufactured by solid freeform fabrication

Challis, VJ, Roberts, AP, Grotowski, JF, Zhang, LC and Sercombe, TB (2010) Prototypes for bone implant scaffolds designed via topology optimization and manufactured by solid freeform fabrication. Advanced Engineering Materials, 12 11: 1106-1110. doi:10.1002/adem.201000154


Author Challis, VJ
Roberts, AP
Grotowski, JF
Zhang, LC
Sercombe, TB
Title Prototypes for bone implant scaffolds designed via topology optimization and manufactured by solid freeform fabrication
Journal name Advanced Engineering Materials   Check publisher's open access policy
ISSN 1438-1656
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1002/adem.201000154
Volume 12
Issue 11
Start page 1106
End page 1110
Total pages 5
Place of publication Weinheim, Germany.
Publisher Wiley - V C H Verlag GmbH
Collection year 2011
Language eng
Abstract The linking of computational design with precision solid freeform fabrication has tremendous potential for producing tissue scaffolds with tailored properties. We consider a new approach to optimizing the architecture of scaffolds based on jointly maximizing scaffold stiffness and diffusive transport in the interconnected pores. The stiffness of the scaffolds is matched to that of bone by choosing a suitable scaffold porosity. Moreover, the templates can be scaled to achieve target pore sizes whilst preserving their elastic and diffusive properties. The resultant structures have two major design benefits. First, the scaffolds do not have directions of low stiffness. In contrast, the Young's modulus of conventional layered-grid designs can be 86% less under diagonally-aligned loads than under axis-aligned loads. Second, the mass of the scaffold is used efficiently throughout the structure rather than being clumped in non load-bearing regions. We fabricate prototypes of the implants using selective laser melting and test their elastic properties. Excellent agreement between theory and experiment provides important confirmation of the viability of this route to scaffold design and fabrication. Topology optimization is used to obtain designs for bone implant scaffolds that are manufactured with selective laser melting (see image). The measured Young's modulus of the scaffold prototypes provides excellent agreement with finite element calculations, confirming the viability of this route to scaffold design and fabrication. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keyword Mechanical-properties
Elastic properties
Tissue
Architecture
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2011 Collection
 
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Created: Sun, 16 Jan 2011, 00:14:13 EST