The central role of RNA in the genetic programming of complex organisms

Mattick, John S. (2010) The central role of RNA in the genetic programming of complex organisms. Anais da Academia Brasileira de Ciencias, 82 4: 933-939. doi:10.1590/S0001-37652010000400016


Author Mattick, John S.
Title The central role of RNA in the genetic programming of complex organisms
Journal name Anais da Academia Brasileira de Ciencias   Check publisher's open access policy
ISSN 0001-3765
1678-2690
Publication date 2010-12
Sub-type Article (original research)
DOI 10.1590/S0001-37652010000400016
Open Access Status DOI
Volume 82
Issue 4
Start page 933
End page 939
Total pages 7
Place of publication Rio de Janeiro, Brazil
Publisher Academia Brasileira de Ciencias
Collection year 2011
Language eng
Abstract Notwithstanding lineage-specific variations, the number and type of protein-coding genes remain relatively static across the animal kingdom. By contrast there has been a massive expansion in the extent of genomic non-proteincoding sequences with increasing developmental complexity. These non-coding sequences are, in fact, transcribed in a regulated manner to produce large numbers of large and small non-protein-coding RNAs that control gene expression at many levels including chromatin architecture, post-transcriptional processing and translation. Moreover, many RNAs are edited, especially in the nervous system, which may be the basis of epigenome-environment interactions and the function of the brain.
Keyword Development
Noncoding RNA
Epigenome
Gene regulation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sun, 16 Jan 2011, 00:14:01 EST