The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization

Lévesque, J.-P., Helwani, F. M. and Winkler, I. G. (2010) The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia, 24 12: 1979-1992. doi:10.1038/leu.2010.214


Author Lévesque, J.-P.
Helwani, F. M.
Winkler, I. G.
Title The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization
Journal name Leukemia   Check publisher's open access policy
ISSN 0887-6924
1476-5551
Publication date 2010-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/leu.2010.214
Volume 24
Issue 12
Start page 1979
End page 1992
Total pages 14
Editor N. Muller-Bérat Killmann
Place of publication London, U.K.
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
The concept of hematopoietic stem cell (HSC) niche was formulated in 1978, but HSC niches remained unidentified for the following two decades largely owing to technical limitations. Sophisticated live microscopy techniques and genetic manipulations have identified the endosteal region of the bone marrow (BM) as a preferential site of residence for the most potent HSC- able to reconstitute in serial transplants- with osteoblasts and their progenitors as critical cellular elements of these endosteal niches. This article reviews the path to the discovery of these endosteal niches (often called osteoblastic niches) for HSC, what cell types contribute to these niches with their known physical and biochemical features. In the past decade, a first wave of research uncovered many mechanisms responsible for HSC homing to, and mobilization from, the whole BM tissue. However, the recent discovery of endosteal HSC niches has initiated a second wave of research focusing on the mechanisms by which most primitive HSC lodge into and migrate out of their endosteal niches. The second part of this article reviews the current knowledge of the mechanisms of HSC lodgment into, retention in and mobilization from osteoblastic niches.
© 2010 Macmillan Publishers Limited All rights reserved.
Keyword Hematopoietic stem cell
Niche
Osteoblast
Bone marrow
Homing
Mobilization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under Spotlight Reviews.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 95 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 105 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 Jan 2011, 00:03:29 EST