Enamel hypoplasia in the primary dentition of monozygotic and dizygotic twins compared with singleton controls

Taji, Sue S., Seow, W. Kim, Townsend, Grant C. and Holcombe, Trevor (2011) Enamel hypoplasia in the primary dentition of monozygotic and dizygotic twins compared with singleton controls. International Journal of Paediatric Dentistry, 20 6: 175-184. doi:10.1111/j.1365-263X.2010.01106.x


Author Taji, Sue S.
Seow, W. Kim
Townsend, Grant C.
Holcombe, Trevor
Title Enamel hypoplasia in the primary dentition of monozygotic and dizygotic twins compared with singleton controls
Journal name International Journal of Paediatric Dentistry   Check publisher's open access policy
ISSN 1365-263X
0960-7439
Publication date 2011-05
Year available 2010
Sub-type Article (original research)
DOI 10.1111/j.1365-263X.2010.01106.x
Volume 20
Issue 6
Start page 175
End page 184
Total pages 10
Place of publication Oxford, England
Publisher Blackwell Scientific
Collection year 2011
Language eng
Formatted abstract
Background.
The study of enamel hypoplasia (EH) and opacity in twins provides insights into the contribution of genetic and environmental factors in the expression of enamel defects.

Aim.
This study examined prevalence and site concordance of EH and opacity in the primary dentition of 2- to 4-year-old twins and singleton controls to assess the relative contribution of genetics and the environment to the aetiology of these defects.

Design. 
The study sample consisted of 88 twin children and 40 singletons aged 2–4 years of age. Medical histories were obtained and the children examined for enamel defects.

Results.
The prevalence of EH by teeth was 21% in monozygotic twins (MZ), 22% in dizygotic twins (DZ), and 15% in singleton controls. Twins showed a higher prevalence of EH compared with singletons (P < 0.05). Factors contributing to increase EH in twins were neonatal complications including intubation. There were no significant differences in site concordance of EH within the MZ twin pairs compared with DZ twin pairs when only presence of EH was considered, whereas a greater concordance was noted between MZ twin pairs compared with DZ twin pairs when both presence and absence of EH were considered.

Conclusions.
The results suggest that both genetic and environmental factors contribute to observed variation of EH, although it is likely that environmental factors exert a greater influence.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 11 Jan 2011, 21:40:30 EST by Professor W. Kim Seow on behalf of School of Dentistry