Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord

Wells, S, Conran, JG, Tamme, R, Gaudin, A, Webb, J and Lardelli, M (2010) Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord. Experimental Cell Research, 316 19: 3292-3303. doi:10.1016/j.yexcr.2010.06.020


Author Wells, S
Conran, JG
Tamme, R
Gaudin, A
Webb, J
Lardelli, M
Title Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord
Journal name Experimental Cell Research   Check publisher's open access policy
ISSN 0014-4827
1090-2422
Publication date 2010-11-15
Sub-type Article (original research)
DOI 10.1016/j.yexcr.2010.06.020
Volume 316
Issue 19
Start page 3292
End page 3303
Total pages 12
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
The molecules and mechanisms involved in patterning the dorsoventral axis of the developing vertebrate spinal cord have been investigated extensively and many are well known. Conversely, knowledge of mechanisms patterning cellular distributions along the rostrocaudal axis is relatively more restricted. Much is known about the rostrocaudal distribution of motoneurons and spinal cord cells derived from neural crest but there is little known about the rostrocaudal patterning of most of the other spinal cord neurons. Here we report data from our analyses of the distribution of dorsal longitudinal ascending (DoLA) interneurons in the developing zebrafish spinal cord. We show that, although apparently distributed irregularly, these cells have cryptic organisation. We present a novel cell-labelling technique that reveals that DoLA interneurons migrate rostrally along the dorsal longitudinal fasciculus of the spinal cord during development. This cell-labelling strategy may be useful for in vivo analysis of factors controlling neuron migration in the central nervous system. Additionally, we show that DoLA interneurons persist in the developing spinal cord for longer than previously reported. These findings illustrate the need to investigate factors and mechanisms that determine "irregular" patterns of cell distribution, particularly in the central nervous system but also in other tissues of developing embryos.
© 2010 Elsevier Inc.
Keyword Dorsal longitudinal ascending interneuron
Cryptic organisation
Neuronal migration
Rostrocaudal patterning
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
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Created: Sun, 09 Jan 2011, 00:07:58 EST