Metabolic syndrome and the risk of Barrett's oesophagus

Kendall, B. J., Macdonald, G. A., Hayward, N. K., Prins, J. B., O'Brien, S., Whiteman, D. C. and for the Study of Digestive Health (2010). Metabolic syndrome and the risk of Barrett's oesophagus. In: Australian Gastroenterology Week 2010, Broadbeach, Qld., Australia, (A78-A78). 20-23 October 2010. doi:10.1111/j.1440-1746.2010.06453.x

Author Kendall, B. J.
Macdonald, G. A.
Hayward, N. K.
Prins, J. B.
O'Brien, S.
Whiteman, D. C.
for the Study of Digestive Health
Title of paper Metabolic syndrome and the risk of Barrett's oesophagus
Conference name Australian Gastroenterology Week 2010
Conference location Broadbeach, Qld., Australia
Conference dates 20-23 October 2010
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
Place of Publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Publication Year 2010
Sub-type Published abstract
DOI 10.1111/j.1440-1746.2010.06453.x
ISSN 0815-9319
Volume 25
Issue Supplement s3
Start page A78
End page A78
Total pages 1
Language eng
Formatted Abstract/Summary
Background The incidence of oesophageal adenocarcinoma (OA) is
increasing rapidly with nearly all OA arising from underlying Barrett’s
oesophagus (BO). The primary risk factors for BO are gastro-oesophageal
refl ux (GOR) and obesity. The risk of obesity remains after controlling for
GOR, suggesting that non-refl ux obesity factors may be important. The
metabolic syndrome (MS) results from obesity related hormonal and systemic
infl ammatory changes and is associated with breast, prostate and
colon cancers. The association between MS and BO is unknown.
Aim To conduct a case-control study to quantify the association between
MS and BO.
Methods We undertook a structured interview, clinical and anthropometric
measures and fasting metabolic and hormonal studies within a
case-control study conducted in Brisbane, Australia. We recruited 236
cases with histologically confi rmed BO diagnosed 2003–6 and 237 controls
from the electoral roll, frequency matched by age and sex to cases.
Odds ratios (OR) and 95% confi dence intervals (CI) were estimated using
multivariable logistic regression analysis.
Results The prevalence of MS was 63% in cases and 47% in controls (p
= 0.0005). There was a signifi cantly increased risk of BO among those
with MS (OR 1.91 95%CI 1.32–2.76). The risk was unaffected in a logistic
regression model adjusting for age, sex, and use of aspirin, NSAIDs,
alcohol and cigarettes (OR 1.91 95%CI 1.27–2.88). Further adjustment for
BMI (OR 1.62 95%CI 1.03–2.54) and GOR (1.34 95%CI 0.80–2.23)
modestly attenuated the association.
Conclusions MS is associated with an increased risk of BO. This association
is not explained simply by higher BMI or GOR among cases. The
mechanism of this association remains unknown but hormonal and systemic
infl ammatory changes associated with obesity are factors warranting
further study.

Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes For the Study of Digestive Health. Published under Gastrointestinal Cancer section

Document type: Conference Paper
Collection: UQ Diamantina Institute Publications
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Created: Sun, 09 Jan 2011, 00:05:01 EST