Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: A feasibility trial

Ng, Norman T.M., Heesch, Kristiann C. and Brown, Wendy J. (2010) Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: A feasibility trial. Arthritis Research & Therapy, 12 1: R25:1-R25:15. doi:10.1186/ar2932


Author Ng, Norman T.M.
Heesch, Kristiann C.
Brown, Wendy J.
Title Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: A feasibility trial
Journal name Arthritis Research & Therapy   Check publisher's open access policy
ISSN 1478-6354
1478-6362
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.1186/ar2932
Open Access Status DOI
Volume 12
Issue 1
Start page R25:1
End page R25:15
Total pages 15
Place of publication London, England, U.K.
Publisher BioMed Central Ltd.
Collection year 2011
Language eng
Formatted abstract
Introduction: Management of osteoarthritis (OA) includes the use of non-pharmacological and pharmacological therapies. Although walking is commonly recommended for reducing pain and increasing physical function in people with OA, glucosamine sulphate has also been used to alleviate pain and slow the progression of OA. This study evaluated the effects of a progressive walking program and glucosamine sulphate intake on OA symptoms and physical activity participation in people with mild to moderate hip or knee OA.

Methods: Thirty-six low active participants (aged 42 to 73 years) were provided with 1500 mg glucosamine sulphate per day for 6 weeks, after which they began a 12-week progressive walking program, while continuing to take glucosamine. They were randomized to walk 3 or 5 days per week and given a pedometer to monitor step counts. For both groups, step level of walking was gradually increased to 3000 steps/day during the first 6 weeks of walking, and to 6000 steps/day for the next 6 weeks. Primary outcomes included physical activity levels, physical function (self-paced step test), and the WOMAC Osteoarthritis Index for pain, stiffness and physical function. Assessments were conducted at baseline and at 6-, 12-, 18-, and 24-week follow-ups. The Mann Whitney Test was used to examine differences in outcome measures between groups at each assessment, and the Wilcoxon Signed Ranks Test was used to examine differences in outcome measures between assessments.

Results: During the first 6 weeks of the study (glucosamine supplementation only), physical activity levels, physical function, and total WOMAC scores improved (P < 0.05). Between the start of the walking program (Week 6) and the final follow-up (Week 24), further improvements were seen in these outcomes (P < 0.05) although most improvements were seen between Weeks 6 and 12. No significant differences were found between walking groups.

Conclusions: In people with hip or knee OA, walking a minimum of 3000 steps (~30 minutes), at least 3 days/week, in combination with glucosamine sulphate, may reduce OA symptoms. A more robust study with a larger sample is needed to support these preliminary findings.

Trial Registration: Australian Clinical Trials Registry ACTRN012607000159459.

Copyright ©2010 Ng et al.; licensee BioMed Central Ltd.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Thu, 06 Jan 2011, 15:17:59 EST