Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny

Gray, Stephen P., Denton, Kate M., Cullen-McEwen, Luise, Bertram, John F. and Moritz, Karen M. (2010) Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny. Journal of the American Society of Nephrology, 21 11: 1891-1902. doi:10.1681/ASN.2010040368


Author Gray, Stephen P.
Denton, Kate M.
Cullen-McEwen, Luise
Bertram, John F.
Moritz, Karen M.
Title Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
1533-3450
1536-836X
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1681/ASN.2010040368
Volume 21
Issue 11
Start page 1891
End page 1902
Total pages 12
Place of publication Washington, DC, United States
Publisher American Society of Nephrology
Collection year 2011
Language eng
Abstract Prenatal ethanol exposure is teratogenic, but the effects of ethanol on kidney development and the health of offspring are incompletely understood. Our objective was to investigate the effects of acute ethanol exposure during pregnancy on nephron endowment, mean arterial pressure, and renal function in offspring. We administered ethanol or saline by gavage to pregnant Sprague-Dawley rats on embryonic days 13.5 and 14.5. At 1 month of age, the nephron number was 15% lower and 10% lower in ethanol-exposed males and females, respectively, compared with controls. Mean arterial pressure, measured in conscious animals via indwelling tail-artery catheter, was 10% higher in both ethanolexposed males and females compared with controls. GFR was 20% higher in ethanol-exposed males but 15% lower in ethanol-exposed females; moreover, males had increased proteinuria compared with controls. Furthermore, embryonic kidneys cultured in the presence of ethanol for 48 hours had 15% fewer ureteric branch points and tips than kidneys cultured in control media. Taken together, these data demonstrate that acute prenatal ethanol exposure reduces the number of nephrons, possibly as a result of inhibited ureteric branching morphogenesis, and that these changes affect adult cardiovascular and renal function. © 2010 by the American Society of Nephrology.
Keyword Ethanol exposure
Nitric oxide
Kidney development
Sexual-dimorphism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
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Created: Sun, 26 Dec 2010, 00:03:39 EST