The plasma membrane calcium pump - a physiological perspective on its regulation

Monteith, G.R. and Roufogalis, B.D. (1995) The plasma membrane calcium pump - a physiological perspective on its regulation. Cell Calcium, 18 6: 459-470. doi:10.1016/0143-4160(95)90009-8


Author Monteith, G.R.
Roufogalis, B.D.
Title The plasma membrane calcium pump - a physiological perspective on its regulation
Journal name Cell Calcium   Check publisher's open access policy
ISSN 0143-4160
1532-1991
Publication date 1995-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/0143-4160(95)90009-8
Volume 18
Issue 6
Start page 459
End page 470
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Churchill Livingstone
Language eng
Formatted abstract
This review focuses on the physiological role of the plasma membrane Ca2+ + Mg2+-dependent adenosine triphosphatase (PM Ca2+-ATPase) in cellular signalling. Particular attention has been paid to the regulation of the PM Ca2+-ATPase (PM Ca2+ pump) by calmodulin, proteases, protein kinases, acidic phospholipids and oligomerization in intact cells. We also review recent work investigating the possible regulation of the PM Ca2+ pump by G proteins and agonists. The source of adenosine triphosphate (ATP) and Ca2+ in fuelling and activating the Ca2+ pump is discussed, as well as the possible role of the PM Ca2+-ATPase in subplasmamembrane Ca2+ regulation. The physiological implication of the localisation of the PM Ca2+ pump in caveolae is also considered.
Keyword Vascular Smooth-muscle
Protein-kinase-c
Ca-2+ Pump
Erythrocyte-membranes
Ca2+ Pump
Inositol Trisphosphate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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Created: Tue, 21 Dec 2010, 00:20:07 EST