Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine

Shaw, P.N., Houston, J.B., Rowland, M., Hopkins, K., Thiercrlin, J.F. and Morselli, P.L. (1985) Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine. British Journal of Clinical Pharmacology, 20 6: 611-618.


Author Shaw, P.N.
Houston, J.B.
Rowland, M.
Hopkins, K.
Thiercrlin, J.F.
Morselli, P.L.
Title Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0306-5251
1365-2125
Publication date 1985-12
Sub-type Article (original research)
Volume 20
Issue 6
Start page 611
End page 618
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Antipyrine total clearance and the formation clearance of its major metabolites were studied in normal, healthy male volunteers before and after multiple dosing for approximately three weeks with phenytoin (six subjects) and carbamazepine (six subjects). Total antipyrine clearance increased on average by 91% after phenytoin dosing and by 61% after carbamazepine and individual increases correlated well with mean plasma concentrations of the anti-epileptic drug. The increase in total clearance resulted largely from increased formation clearances of the 4- hydroxy and 3-hydroxymethylantipyrine metabolites with minimal effect on the norantipyrine pathway, following treatment with both enzyme- inducing drugs. It is concluded that both phenytoin and carbamazepine have similar effects on antipyrine metabolism and that these effects are mediated by induction of specific forms of cytochrome P450.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 26 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 14:10:37 EST