Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats

Shaw, P.N. and Houston, J.B. (1986) Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats. Toxicology and Applied Pharmacology, 84 2: 232-240. doi:10.1016/0041-008X(86)90130-4


Author Shaw, P.N.
Houston, J.B.
Title Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats
Journal name Toxicology and Applied Pharmacology   Check publisher's open access policy
ISSN 0041-008X
1096-0333
Publication date 1986-06
Sub-type Article (original research)
DOI 10.1016/0041-008X(86)90130-4
Volume 84
Issue 2
Start page 232
End page 240
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
The in vivo consequences of a single dose of Aroclor 1254 (50 mg/kg) on the drug metabolizing capacity of rats were investigated. A noninvasive method, employing [N-methyl-14C]-antipyrine where both 14CO2 exhalation and urinary excretion of 4-hydroxy-, 3-hydroxymethyl-, and norantipyrine were monitored, was used. A group of rats were sequentially tested over a 3-week period to characterize temporal patterns. The antipyrine metabolite kinetic approach demonstrated that induction of hepatic cytochrome P-450 is maximal 3-6 days after Aroclor 1254 administration and the effects were apparent for at least a further 14-17 days. Evidence is presented to suggest selective effects of Aroclor 1254 on different cytochromes P-450 are apparent in vivo.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 14:10:27 EST