Nasal administration of morphine-6-glucuronide in sheep - A pharmacokinetic study

Illum, L., Davis, S.S., Pawula, M., Fisher, A.N., Barrett, D.A., Farraj, N.F. and Shaw, P.N. (1996) Nasal administration of morphine-6-glucuronide in sheep - A pharmacokinetic study. Biopharmaceutics and Drug Disposition, 17 8: 717-724. doi:10.1002/(SICI)1099-081X(199611)17:8<717::AID-BDD985>3.0.CO;2-I


Author Illum, L.
Davis, S.S.
Pawula, M.
Fisher, A.N.
Barrett, D.A.
Farraj, N.F.
Shaw, P.N.
Title Nasal administration of morphine-6-glucuronide in sheep - A pharmacokinetic study
Journal name Biopharmaceutics and Drug Disposition   Check publisher's open access policy
ISSN 0142-2782
1099-081X
Publication date 1996-11
Sub-type Article (original research)
DOI 10.1002/(SICI)1099-081X(199611)17:8<717::AID-BDD985>3.0.CO;2-I
Volume 17
Issue 8
Start page 717
End page 724
Total pages 8
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
The pharmacokinetics of morphine-6-glucuronide (M6G) after both intravenous dosing and nasal administration were studied in sheep. The nasal formulation consisted of M6G in combination with an absorption promoting delivery system in the form of chitosan. The mean half-life of M6G after intravenous administration was 51·0±8·2 min and that after intranasal dosing was 45·0±5·5 min. M6G clearance and volume of distribution were 5·4±1·5 mL min±1 kg±1 and 0·4±0·1 L kg±1 respectively. The plasma profile after nasal administration demonstrated rapid absorption of M6G. The bioavailability of M6G in the chitosan formulation was found to be 31·4%. These results suggest that M6G administered in combination with the chitosan delivery system may be considered as a suitable non-parenteral means of administering this analgesic.
Keyword Morphine-6-glucuronide
Nasal
Chitosan
Sheep Model
Pharmacokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 4 December 1998.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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