The pharmacokinetics and physiological effects of buprenorphine infusion in premature neonates

Barrett, D.A., Simpson, J., Rutter, N., Kuriharabergstrom, T., Shaw, P.N. and Davis, .S. (1993) The pharmacokinetics and physiological effects of buprenorphine infusion in premature neonates. British Journal of Clinical Pharmacology, 36 3: 215-219.


Author Barrett, D.A.
Simpson, J.
Rutter, N.
Kuriharabergstrom, T.
Shaw, P.N.
Davis, .S.
Title The pharmacokinetics and physiological effects of buprenorphine infusion in premature neonates
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0306-5251
1365-2125
Publication date 1993-09
Sub-type Article (original research)
Volume 36
Issue 3
Start page 215
End page 219
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
1. The pharmacokinetics and physiological effects of buprenorphine were studied in 12 newborn premature neonates (27 to 32 weeks gestational age) who were given a loading dose of 3.0 micrograms kg-1 of buprenorphine followed by an intravenous infusion of 0.72 micrograms kg- 1 h-1 of buprenorphine. Plasma concentrations of buprenorphine were measured during the infusion, at steady-state and for 24 h after the cessation of the buprenorphine infusion.

2. The mean steady-state plasma buprenorphine concentration (+/- s.d.) for an infusion rate of 0.72 micrograms kg-1 h-1 was 4.3 +/- 2.6 ng ml-1.

3. Buprenorphine clearance was 0.23 +/- 0.07 l h-1 kg-1, the elimination half-life was 20 +/- 8 h and the volume of distribution was 6.2 +/- 2.11 l kg-1.

4. Small but significant falls were noted in systolic blood pressure at 6 h and heart rate at 1, 6 and 12 h after the administration of buprenorphine, but these did not appear to cause any clinical deterioration.

5. Four of the 12 subjects studied required an increase in the infusion rate of buprenorphine to achieve adequate sedation.

6. The results suggest that this dosing regimen of buprenorphine is safe but may not be as effective as other opioids in producing sedation and analgesia in premature newborns.
Keyword Buprenorphine
Pharmacokinetics
Premature Newborn
Intravenous Infusion
Dose Regimen
Diamorphine Infusion
Morphine
Children
Pain
Metabolites
Stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 5 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 14:04:20 EST