Morphine kinetics after diamorphine infusion in premature neonates

Barrett, D.A., Elias-Jones, A.C., Rutter, N., Shaw, P.N. and Davis, S.S. (1991) Morphine kinetics after diamorphine infusion in premature neonates. British Journal of Clinical Pharmacology, 32 1: 31-37.

Author Barrett, D.A.
Elias-Jones, A.C.
Rutter, N.
Shaw, P.N.
Davis, S.S.
Title Morphine kinetics after diamorphine infusion in premature neonates
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0306-5251
Publication date 1991-07
Sub-type Article (original research)
Volume 32
Issue 1
Start page 31
End page 37
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
1. The pharmacokinetics of morphine were studied in 26 newborn premature neonates (26-38 weeks gestational age) who were given a loading dose of 50 micrograms kg-1 of diamorphine followed by an intravenous infusion of 15 micrograms kg-1 h-1 of diamorphine. Plasma concentrations of morphine were measured during the infusion at steady- state and for 24 h after the cessation of the diamorphine infusion.

2. The mean steady-state plasma morphine concentration (+/- s.d.) for a diamorphine infusion rate of 15 micrograms kg-1 h-1 was 62.5 +/- 22.8 ng ml-1.

3. Morphine clearance was 3.6 +/- 0.9 ml min-1 kg-1, the elimination half-life was 8.9 +/- 3.3 h and the volume of distribution was 2.7 +/- 1.01 kg-1.

4. Morphine elimination kinetics were described by a mono-exponential function.

5. There was a direct relationship between the gestational age of the patients and the clearance (r2 = 0.31, P = 0.003) and half-life (r2 = 0.35, P = 0.01) of morphine, but no relationship was found between gestational age and volume of distribution.

6. The results suggest that the currently used dosing regimen of diamorphine achieves a safe and effective morphine concentration in the premature newborn but that the loading dose could be modified to achieve a more rapid onset of analgesia.
Keyword Diamorphine
Premature Newborn
Intravenous Infusion
Dose Regimen
Early Infancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 26 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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Created: Mon, 20 Dec 2010, 14:03:59 EST