The effect of temperature and pH on the deacetylation of diamorphine in aqueous solution and in human plasma

Barrett, D.A., Dyssegaard, A.L.P. and Shaw, P.N. (1992) The effect of temperature and pH on the deacetylation of diamorphine in aqueous solution and in human plasma. Journal of Pharmacy and Pharmacology, 44 7: 606-608.


Author Barrett, D.A.
Dyssegaard, A.L.P.
Shaw, P.N.
Title The effect of temperature and pH on the deacetylation of diamorphine in aqueous solution and in human plasma
Journal name Journal of Pharmacy and Pharmacology   Check publisher's open access policy
ISSN 0022-3573
2042-7158
Publication date 1992-07
Sub-type Other
Volume 44
Issue 7
Start page 606
End page 608
Total pages 3
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract The effect of temperature on the kinetics of the deacetylation of diamorphine and 6-monoacetylmorphine was studied in human plasma. Diamorphine was rapidly and quantitatively degraded to 6-monoacetylmorphine with initial half-lives of 354, 18 and 3 min at temperatures of 4, 25 and 37°C, respectively. Further deacetylation to morphine was not detected. In aqueous solution, diamorphine was quantitatively degraded to give 6-monoacetylmorphine as the major product and morphine as a minor product, the rate of deacetylation being dependent on temperature and pH. At pH 4·0 and 5·6 diamorphine had a half-life of greater than 14 days at all temperatures but at alkaline pH diamorphine was rapidly deacetylated. The rate of deacetylation of 6-monoacetylmorphine was consistently slower than that of diamorphine under identical conditions of pH and temperature. A method is described for the rapid stabilization and subsequent assay of diamorphine in plasma which will prevent errors in estimation of the drug due to unwanted hydrolysis.
Keyword Diacetylmorphine Heroin
Human-serum
Pharmacokinetics
Metabolites
Stability
Infusion
Blood
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 12 April 2011.

Document type: Journal Article
Sub-type: Other
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 14:03:54 EST