Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations

Cottrell, W.N. and Fitzpatrick, R.W. (1986) Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations. Journal of Clinical and Hospital Pharmacy, 11 5: 335-342. doi:10.1111/j.1365-2710.1986.tb00861.x


Author Cottrell, W.N.
Fitzpatrick, R.W.
Title Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations
Journal name Journal of Clinical and Hospital Pharmacy   Check publisher's open access policy
ISSN 0143-3180
Publication date 1986-10-01
Sub-type Article (original research)
DOI 10.1111/j.1365-2710.1986.tb00861.x
Volume 11
Issue 5
Start page 335
End page 342
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations were determined by utilizing high-performance liquid chromatography techniques following a once daily irrigation. A total of 14 chlorhexidine irrigations established a mean concentration of 0.006% w/v, 2-3 h post irrigation. A total of 12 noxythiolin irrigations established a mean concentration of 0.266% w/v, 2-3 h post irrigation, which correlated to a mean formaldehyde concentration of 0.0119% w/v at 2-3 h, as estimated from N-methylthiourea. For both solutions the minimum inhibitory concentration was exceeded for up to 5 h post irrigation, which is sufficient contact time to establish a total kill, thus indicating the possibility that a once daily irrigation may be appropriate in asymptomatic bacteriuria which utilizes either chlorhexidine or noxythiolin.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 28 June 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Tue, 21 Dec 2010, 00:00:13 EST