Pharmacokinetics of cisapride in the horse

Steel, C.M., Bolton, T.R., Preechagoon, Y. and Charles, B.G. (1998) Pharmacokinetics of cisapride in the horse. Journal of Veterinary Pharmacology and Therapeutics, 21 6: 433-436. doi:10.1046/j.1365-2885.1998.00168.x

Author Steel, C.M.
Bolton, T.R.
Preechagoon, Y.
Charles, B.G.
Title Pharmacokinetics of cisapride in the horse
Journal name Journal of Veterinary Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0140-7783
Publication date 1998-12
Sub-type Article (original research)
DOI 10.1046/j.1365-2885.1998.00168.x
Volume 21
Issue 6
Start page 433
End page 436
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The purpose of this study was to determine the pharmacokinetics and absolute bioavailability of cisapride after intravenous (i.v.) and intragastric (i.g.) administration in healthy, adult horses. Five animals received single doses of 0.1 mg/kg, 0.2 mg/kg and 0.4 mg/kg cisapride by the i.g. route in an open, randomized fashion on different occasions separated by a washout period of at least 48 h. Four of these horses were also given a single i.v. dose of 0.1 mg/kg cisapride. Jugular venous blood was collected periodically up to 24 h after dosing. Plasma cisapride concentrations were measured by high-performance liquid chromatography. There was considerable inter individual variability in pharmacokinetic parameters. The mean (SD) values for systemic clearance (Cl) and steady-state volume of distribution (Vss) were 494 (43.6) mL/h/kg and 1471 (578) mL/kg, respectively. Although the rate of cisapride absorption was quite rapid, only about half the i.g. dose was absorbed systemically. The average terminal halflife (t( 1/2 ) ) calculated over three i.g. doses was 2.06 h and that for i.v. administration was 2.12 h. The pharmacokinetics of cisapride from 0.1 mg/ kg to 0.4 mg/kg were independent of the i.g. dose.
Keyword Intestine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article first published online: 5 January 2002.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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Created: Mon, 20 Dec 2010, 13:57:08 EST