Transient-evoked and 2F1-F2 distortion product oto-acoustic emissions in dogs: preliminary findings

Sockalingam, Ravi, Filippich, Lucio, Sommerlad, Sue, Murdoch, Bruce and Charles, Bruce (1998) Transient-evoked and 2F1-F2 distortion product oto-acoustic emissions in dogs: preliminary findings. Audiology and Neurotology, 3 6: 373-385. doi:10.1159/000013807


Author Sockalingam, Ravi
Filippich, Lucio
Sommerlad, Sue
Murdoch, Bruce
Charles, Bruce
Title Transient-evoked and 2F1-F2 distortion product oto-acoustic emissions in dogs: preliminary findings
Formatted title
Transient-evoked and 2F1-F2 distortion product oto-acoustic emissions in dogs: preliminary findings
Journal name Audiology and Neurotology   Check publisher's open access policy
ISSN 1420-3030
1421-9700
Publication date 1998-11
Sub-type Article (original research)
DOI 10.1159/000013807
Volume 3
Issue 6
Start page 373
End page 385
Total pages 13
Place of publication Basel, Switzerland
Publisher Karger
Language eng
Formatted abstract
Transient (click)-evoked oto-acoustic emissions (TEOAEs) and distortion product oto-acoustic emissions (DPOAEs) were recorded in a feasibility study in 7 healthy mixed-breed dogs using the ILO 92 OAE analyser (Otodynamics, Hartfield, UK). Five dogs were found to have normal hearing in both ears and 2 dogs in the left ear only following otoscopy, tympanometry and auditory brainstem response audiometry. Twelve sets of TEOAEs (click-evoked) to 80 dB peSPL click stimulus and 9 sets of DPOAEs (2F1-F2) to 8 different stimulus levels of the primary tones (L1/L2) were collected at 11 test frequencies (F2) in these normal-hearing dogs. TEOAEs were successfully recorded in 11 of the 12 ears using the default user setting and in all 12 ears using the quickscreen program. DPOAEs were successfully recorded in all 9 ears tested. While the TEOAEs parameters matched those for humans, the average signal-to-noise ratio of DPOAEs was considerably higher in the dogs. Stimulus levels at 55/55, 55/45 and 55/35 dB SPL were demonstrated to produce DPOAEs that seem to reflect the active dynamic status of the outer hair cell system. Postmortem DPOAEs at these stimulus levels and TEOAEs at 80 Db peSPL could not be elicited 5 min following euthanasia of dogs. However, DPOAEs could still be recorded albeit with reduced amplitude at stimulus levels where L1 > 55 dB SPL. The results suggest that TEOAEs and DPOAEs in dogs have the potential to provide valuable insights into their mechanisms of generation, and the specific role and behaviour of outer hair cells of the cochlea in certain pathological conditions, particularly in drug-induced ototoxicity, in humans.
Keyword Oto-acoustic emission
Transient-evoked distortion product
Dog
Animal model
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Health and Rehabilitation Sciences Publications
School of Pharmacy Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 20 Dec 2010, 13:57:00 EST