Individualizing aminophylline doses in premature infants using bioelectrical impedance: a non-invasive approach

Sidhu, J., Triggs, E., Charles, B., Tudehope, D., Gray, P. and Cowley, D. (1993) Individualizing aminophylline doses in premature infants using bioelectrical impedance: a non-invasive approach. Journal of Paediatrics and Child Health, 29 2: 113-118.


Author Sidhu, J.
Triggs, E.
Charles, B.
Tudehope, D.
Gray, P.
Cowley, D.
Title Individualizing aminophylline doses in premature infants using bioelectrical impedance: a non-invasive approach
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
1440-1754
Publication date 1993-04
Sub-type Article (original research)
Volume 29
Issue 2
Start page 113
End page 118
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
The role of bioelectrical impedance (BI) in estimating the pharmacokinetics and, therefore, individualized doses, of aminophylline in preterm infants (gestational age 26–35 weeks) was assessed in a two-phase study. Multiple regression analysis in the first group of neonates (phase I, n= 19) identified resistance, reactance, weight and length as optimal predictors of distribution volume (adjusted R2= 0.84, coefficient of variation (CV) = 10.17%), and length2/impedance and postconceptual age as predictors of clearance (adjusted R2= 0.74, CV = 26.73%). Application of these models to an independent group (phase II, n= 20) generated doses which satisfactorily achieved target theophylline loading and steadystate (SS) ‘peaks’ of 10 μg/mL and SS ‘troughs’ of 7.7±0.6 μg/mL. A better understanding of specific criteria and limitations of the impedance technique in neonates is necessary in order to refine BI measurements.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Erratum: Individualizing aminophylline doses in premature infants using bioelectrical impedance: A non-invasive approach (J. Paediatr. Child Health 1993; 29(2): 113-18)

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 13:56:44 EST