Individual theophylline dosing based on bioelectrical impedance analysis

Sidhu, J.S., Triggs, E.J., Charles, B.G. and Smithurst, B.A. (1993) Individual theophylline dosing based on bioelectrical impedance analysis. British Journal of Clinical Pharmacology, 35 6: 657-660. doi:10.1111/j.1365-2125.1993.tb04198.x

Author Sidhu, J.S.
Triggs, E.J.
Charles, B.G.
Smithurst, B.A.
Title Individual theophylline dosing based on bioelectrical impedance analysis
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0306-5251
Publication date 1993-06
Sub-type Article (original research)
DOI 10.1111/j.1365-2125.1993.tb04198.x
Volume 35
Issue 6
Start page 657
End page 660
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
The role of bioelectrical impedance (BI) analysis in determining slow-release theophylline dosage was evaluated in fifteen healthy subjects given a standard 200 mg dose. Reactance and l/resistance were identified as the most significant predictors of pre-dose, steady-state theophylline concentrations (C(ss,pre)). Compared with doses based on body weight (8.8 mg kg-1 day-1), theophylline doses determined by BI analysis (9.6 ± 2.4 mg kg-1 day-1) resulted in less biased (mean prediction error = 0.6 vs 1.4) though slightly less precise (mean squared error = 7.1 vs 6.3) C(ss,pre) values. These differences were statistically insignificant (P > 0.05).
Keyword Theophylline
Bioelectrical impedance
Predictive models
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article first published online: 5 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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Created: Mon, 20 Dec 2010, 13:56:32 EST