Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates

Harte, G.J., Gray, P.H., Lee, T.C., Steer, P.A. and Charles, B.G. (1997) Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates. Journal of Paediatrics and Child Health, 33 4: 335-338. doi:10.1111/j.1440-1754.1997.tb01611.x


Author Harte, G.J.
Gray, P.H.
Lee, T.C.
Steer, P.A.
Charles, B.G.
Title Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
1440-1754
Publication date 1997-08
Sub-type Article (original research)
DOI 10.1111/j.1440-1754.1997.tb01611.x
Volume 33
Issue 4
Start page 335
End page 338
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective:
To evaluate the effects of intravenous midazolam on haemodynamic variables and cerebral blood flow velocity (CBFV) and to determine the pharmacokinetics using a population approach in very low birthweight (VLBW) ventilated infants.

Methodology:

Physiological variables were measured at predetermined times in 10 infants with birthweight ≤1500 g following a bolus dose of intravenous midazolam (0.1 mg/kg). Heart rate, mean arterial blood pressure (MAP) and transcutaneous CO2 (TcPCO2) were recorded and CBFV was assessed by Doppler ultrasound. Midazolam concentrations were also measured and pharmacokinetic parameters determined using a population modelling package.

Results:
No change in heart rate occurred during the study period, while the MAP decreased by 3 mmHg 5 min after midazolam administration compared to baseline values. A non-significant fall in TcPCO2 was seen at 20 min. Mean CBFV decreased from the baseline by 12% at 5 min, then returning to predose values. Midazolam concentrations were in the range shown to be effective in sedation of paediatric intensive care infants with the elimination being delayed in comparison to older children.

Conclusions:
As only minor cerebral and haemodynamic effects were found with the use of midazolam in stable ventilated preterm infants, it appears to be a safe, short-term sedative agent.
Keyword Cerebral blood flow velocity
Midazolam
Pharmacokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article first published online: 10 March 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 13:52:59 EST