Pharmacokinetics and bioavailability of flucloxacillin in elderly hospitalized patients

Gath, J., Charles, B., Sampson, J. and Smithurst, B. (1995) Pharmacokinetics and bioavailability of flucloxacillin in elderly hospitalized patients. Journal of Clinical Pharmacology, 35 1: 31-36. doi:10.1002/j.1552-4604.1995.tb04742.x


Author Gath, J.
Charles, B.
Sampson, J.
Smithurst, B.
Title Pharmacokinetics and bioavailability of flucloxacillin in elderly hospitalized patients
Journal name Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0091-2700
1552-4604
Publication date 1995-01
Sub-type Article (original research)
DOI 10.1002/j.1552-4604.1995.tb04742.x
Volume 35
Issue 1
Start page 31
End page 36
Total pages 6
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Abstract The pharmacokinetics and oral bioavailability of flucloxacillin were studied in five female and two male patients (age 68-87 yr) who had been hospitalized for orthopedic surgeries. A single dose of intravenous or oral flucloxacillin sodium (500 mg) was administered in random order on different occasions separated by at least 2 days. Blood and urine samples were taken up to 24 hours after drug administration and levels of flucloxacillin and 5- hydroxymethylflucloxacillin (5-HMF), a major metabolite, were measured by high-performance liquid chromatography. Flucloxacillin elimination, but not oral absorption, was reduced in the elderly, compared with data from young healthy subjects reported elsewhere. Total clearance, renal clearance, and volume of distribution were 0.083 ± 0.013 L/kg/hr, 0.038 ± 0.01 L/kg/hr, and 0.184 ± 0.034 L/kg, respectively. Regression of flucloxacillin renal clearance (Cl(r)) on estimated creatinine clearance (CL(cr)) gave the relationship: CI(r) = 0.755 (CL(cr)) ± 10.6 (r = 0.91; P = 0.004). Terminal half-lives for flucloxacillin and 5-HMF were 2.21 ± 0.51 hr and 3.0 ± 0.75 hr, respectively, after intravenous administration. Flucloxacillin was absorbed rapidly after oral administration, with a mean absorption time of 0.95 ± 0.34 hr, and time to reach peak concentration of 1.20 ± 0.29 hr. The absolute bioavailability of flucloxacillin from capsules was 54.4 ± 18.8%.
Keyword Beta lactam antibiotics
Amoxicillin absorption
Metabolites
Infants
Program
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 13:52:44 EST