Antagonism of sodium amoxycillin absorption in man following oral administration with glycyl-peptides

Chulavatnatol, S. and Charles, B. (1994) Antagonism of sodium amoxycillin absorption in man following oral administration with glycyl-peptides. European Journal of Pharmaceutics and Biopharmaceutics, 40 6: 374-378.

Author Chulavatnatol, S.
Charles, B.
Title Antagonism of sodium amoxycillin absorption in man following oral administration with glycyl-peptides
Journal name European Journal of Pharmaceutics and Biopharmaceutics   Check publisher's open access policy
ISSN 0939-6411
1873-3441
Publication date 1994-12
Sub-type Article (original research)
Volume 40
Issue 6
Start page 374
End page 378
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The effect of glycyl-peptides on the absorption of amoxycillin sodium was studied in 4 healthy, young adults. Amoxycillin was assayed in urine by HPLC. The initial (0-0.5 h) excretion rate of amoxycillin was significantly (p < 0.05) reduced when 25 mmol diglycine, triglycine, glycylleucine, glycyltyrosine or glycylproline, was administered with 0.25 mmol amoxycillin sodium. The maximum reduction (81%) occurred when amoxycillin was given with glycylproline. Significantly longer mean residence times were observed after administration with glycylleucine, glycyltyrosine and glycylproline, compared with amoxycillin alone. Triglycine (25 mmol) gave similar results to diglycine, but glycine (25 mmol) had no significant effect on amoxycillin absorption. Administration of peptides had no effect on amoxycillin elimination half-life or urine flow rate. A sigmoidal dose-response curve was obtained when glycylproline dose was plotted against reduction in initial amoxycillin excretion rate. Preliminary enzymatic kinetic analyses of these data in 3 subjects gave K(i) values ranging from 3 mmol to 11.5 mmol for glycylproline. Collectively, these results indicated that the absorption of amoxycillin from the human intestine may occur via the carrier system used by di- and tripeptides, but not amino acids.
Keyword Absorption
Amoxycillin
Glycyl-peptides
Intestin al peptide carrier system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Mon, 20 Dec 2010, 13:51:38 EST