Comparative bioavailability study of theophylline tablets marketed in Australasia

Charles, B. G., Ravenscroft, P. J. and Bochner, F. (1980) Comparative bioavailability study of theophylline tablets marketed in Australasia. Medical Journal of Australia, 2 5: 264-266.

Author Charles, B. G.
Ravenscroft, P. J.
Bochner, F.
Title Comparative bioavailability study of theophylline tablets marketed in Australasia
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
1326-5377
Publication date 1980-01-01
Sub-type Article (original research)
Volume 2
Issue 5
Start page 264
End page 266
Total pages 3
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing Company
Language eng
Abstract Average peak concentrations of theophylline in plasma (range, 15 mumol/L) were not significantly different when Nuelin, Brondecon and Choledyl tablets were administered to healthy subjects. The fraction of the theophylline dose absorbed from these preparations was comparable (range, 0.82 to 0.90). In contrast, the absorption of theophylline was significantly different (P < 0.001) when the times to reach peak theophylline concentration were compared. Mean peak theophylline concentrations were achieved 1.5 hours after administration of either Nuelin or Brondecon tablets and nine hours after Choledyl administration. Nuelin and Brondecon are considered to be bioequivalent. Choledyl may be used when side effects caused by rapid theophylline absorption are to be avoided.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 23:49:39 EST