Population pharmacokinetics of intravenous amoxicillin in very low birth weight infants

Charles, Bruce G., Preechagoon, Yupaporn, Lee, Toong C., Steer, Peter A., Flenady, Vicki J. and Debuse, Nicola (1997) Population pharmacokinetics of intravenous amoxicillin in very low birth weight infants. Journal of Pharmaceutical Sciences, 86 11: 1288-1292. doi:10.1021/js970068l

Author Charles, Bruce G.
Preechagoon, Yupaporn
Lee, Toong C.
Steer, Peter A.
Flenady, Vicki J.
Debuse, Nicola
Title Population pharmacokinetics of intravenous amoxicillin in very low birth weight infants
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
Publication date 1997-11
Sub-type Article (original research)
DOI 10.1021/js970068l
Volume 86
Issue 11
Start page 1288
End page 1292
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
The population pharmacokinetics of amoxicillin were determined in 40 very premature infants (≤32 week gestational age, <1500 g birth weight) who were receiving intravenous amoxicillin (50 mg/kg, every 12 h) during the first days after birth. Serum amoxicillin concentrations were measured by HPLC. Clearance (CL) and volume of distribution (Vd) were modeled alone and under the influence of demographic and clinical covariates with a 1-compartment model with first-order elimination. The final population models with influential covariates were: CL (L/h) = 0.0000610 · body weight (g) and CL (L/h) = 0.0000805 · body weight (g), for infants also receiving gentamicin and not receiving gentamicin, respectively; Vd (L) = 0.678. The interpatient standard deviation (SD) for CL was 0.0351 L/h, and for Vd was 0.365 L. The intrapatient variability (SD) among observed and model-predicted serum concentrations was 13.7 mg/L. Evaluation of the predictive performance of this model in another group of infants (n = 16) indicated statistically insignificant bias (p > 0.05) of 3 mg/L among pairs of observed and Bayesian-predicted amoxicillin concentrations. The average population CL was smaller, but the average Vd and terminal half-life (t1/2) were larger than previously reported for healthy adults.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Pharmacy Publications
Centre for Integrated Preclinical Drug Development Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 20 Dec 2010, 13:49:17 EST