The effects of ingestion time of gliclazide in relationship to meals on plasma glucose, insulin and C-peptide levels

Ma, A., Bird, D., Noble, R., Charles, B., Ravenscroft, P. and Cameron, D. (1990) The effects of ingestion time of gliclazide in relationship to meals on plasma glucose, insulin and C-peptide levels. European Journal of Clinical Pharmacology, 38 5: 465-467. doi:10.1007/BF02336685


Author Ma, A.
Bird, D.
Noble, R.
Charles, B.
Ravenscroft, P.
Cameron, D.
Title The effects of ingestion time of gliclazide in relationship to meals on plasma glucose, insulin and C-peptide levels
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
1432-1041
Publication date 1990
Sub-type Article (original research)
DOI 10.1007/BF02336685
Volume 38
Issue 5
Start page 465
End page 467
Total pages 3
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract The effect of altering the timing of gliclazide administration in relation to a meal was studied in ten type 2 (non-insulin dependent) chronically treated diabetics. Gliclazide was given 30 min before, at the start of and 30 min after breakfast or omitted altogether. Plasma gliclazide was present at greater than 2 mg/l throughout the study periods. Administration at 30 min after the meal significantly delayed the time to peak for plasma gliclazide. No significant difference was noted in plasma glucose, insulin or c-peptide patterns with any protocol. It is concluded that, in clinical practice, with chronically treated diabetics the timing of gliclazide ingestion in relation to meals is not critical.
Keyword c-Peptide
Gliclazide
Insulin
Non-insulin dependent diabetes
Administration time
Plasma glucose
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 13:48:25 EST