Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius)

Ali, B.H., Wong, Y. C., Alhadrami, G. A., Charles, B. G. and Bashir, A. K. (1998) Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius). Research in Veterinary Science, 64 1: 69-72. doi:10.1016/S0034-5288(98)90118-7


Author Ali, B.H.
Wong, Y. C.
Alhadrami, G. A.
Charles, B. G.
Bashir, A. K.
Title Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius)
Formatted title
Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius)
Journal name Research in Veterinary Science   Check publisher's open access policy
ISSN 0034-5288
1532-2661
Publication date 1998-01
Sub-type Article (original research)
DOI 10.1016/S0034-5288(98)90118-7
Volume 64
Issue 1
Start page 69
End page 72
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Single bolus intravenous (i.v.) and intramuscular (i.m.) doses of furosemide (1·5 mg kg−1) were administered in a crossover design to three female and three male adult, dromedary camels. Plasmafurosemide concentrations were assayed by HPLC and sodium, potassium and chloride concentrations were measured using ion-selective electrodes. Plasmafurosemide concentration-time plots indicated multi-compartment disposition, and there was considerable intersubject variability in the pharmacokinetic parameters. The mean (SD) i.v. terminal elimination half-life was 118 (67) minutes. The systemic clearance was 5·4 (1·2) ml min−1 kg−1, and the steady-state volume of distribution was 0·43 (0·14) litre kg−1. The mean absorption time after i.m. dosing was 33 (62) minutes, while the absolute bioavailability was 71 (20) per cent. The glucuronide metabolite of furosemide was not detected in plasma. Clearance was lower, volume of distribution was larger, and half-life was longer compared with published data for dogs, horses, rats and humans. Plasma potassium and sodium concentrations were significantly diminished (P<0·05) by an average of 35·6 per cent (two to six hours post-dose) and 11·3 per cent (eight hours post-dose), respectively. Plasma chloride concentrations were not significantly affected by furosemide administration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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