Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats

Rickman, Celestine, Iyer, Aabishek, Chan, Vincent and Brown, Lindsay (2010) Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats. Current Pharmaceutical Biotechnology, 11 8: 881-886. doi:10.2174/138920110793261980

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Author Rickman, Celestine
Iyer, Aabishek
Chan, Vincent
Brown, Lindsay
Title Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats
Journal name Current Pharmaceutical Biotechnology   Check publisher's open access policy
ISSN 1389-2010
1873-4316
Publication date 2010-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/138920110793261980
Volume 11
Issue 8
Start page 881
End page 886
Total pages 6
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2011
Language eng
Formatted abstract
Excess carbohydrate in the diet may initiate a chronic state of oxidative stress exacerbating the clinical and biochemical symptoms of diet-induced type 2 diabetes, especially glucose intolerance, lipid abnormalities and cardiovascular complications. This study has tested whether green tea, rich in antioxidants, improves both cardiovascular symptoms and glucose intolerance and also reduces oxidative stress in rats fed a high carbohydrate diet. Male 8 week old Wistar rats were fed a diet including fructose and condensed milk (each 40%) for 16 weeks (112 days); control rats were fed corn starch. Green tea-containing food was started from day 1 for the prevention protocol and from day 56 for the reversal protocol. High carbohydrate diet-fed rats showed glucose intolerance, hypertension, mild left ventricular hypertrophy, approximate doubling of cardiac interstitial and perivascular collagen deposition, increased passive diastolic stiffness and increased plasma malondialdehyde concentrations. Administration of green tea to high carbohydrate diet-fed rats prevented and reversed glucose intolerance and the increased systolic blood pressure, left ventricular wet weight, interstitial collagen and passive diastolic stiffness. Plasma malondialdehyde concentrations were also normalized. In summary, treatment with green tea both prevented and reversed the cardiovascular remodeling and metabolic changes seen in high carbohydrate-fed rats suggesting a chronic state of oxidative stress plays a key role in the symptom initiation and progression. Further, green tea may be a useful complementary therapy in diet induced type 2 diabetes.

Keyword Green tea
Remodeling
Obesity
Diabetes
Rats
Oxidative stress
Salt Hypertensive-rats
Cardiac-hypertrophy
Antifibrotic Activity
Insulin-resistance
Oxidative stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Biological Sciences Publications
School of Biomedical Sciences Publications
 
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Created: Sun, 19 Dec 2010, 10:14:34 EST