The folding of disulfide-rich proteins

Craik, David J. (2011) The folding of disulfide-rich proteins. Antioxidants and Redox Signaling, 14 1: 61-64. doi:10.1089/ars.2010.3656

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Author Craik, David J.
Title The folding of disulfide-rich proteins
Journal name Antioxidants and Redox Signaling   Check publisher's open access policy
ISSN 1523-0864
Publication date 2011-01-01
Year available 2010
Sub-type Editorial
DOI 10.1089/ars.2010.3656
Open Access Status File (Author Post-print)
Volume 14
Issue 1
Start page 61
End page 64
Total pages 4
Place of publication New Rochelle, NY, U.S.A.
Publisher Mary Ann Liebert, Publishers
Collection year 2012
Language eng
Formatted abstract
The articles in this forum issue describe various aspects of the folding of disulfide-rich proteins. They include review articles using proteins such as bovine pancreatic trypsin inhibitor as models to highlight the range of folding pathways seen in disulfide-rich proteins, along with a detailed analysis of the methods used to study them. Following two comprehensive reviews on the methods and applications of protein folding, three original articles in this issue focus on two specific classes of disulfide-rich proteins that have applications in drug design and development, namely cyclotides and conotoxins. Cyclotides are head-to-tail cyclic and disulfide-rich proteins from plants and function as a defense against insect attack. Conotoxins are the disulfide-rich components of the venom of marine cone snails that is used to capture prey. These research articles report on factors that modulate protein folding pathways in these molecules and determine the outcomes of protein folding, that is, yield and heterogeneity of products. Finally, the issue concludes with a comprehensive review on a different type of disulfide bond, namely those that have a functional rather than structural role in proteins, with a particular focus on allosteric disulfide bonds that modify protein function.
Keyword Cyclic cystine knot
Macrocyclic peptides
Structural motif
Plant cyclotides
Drug design
Kalata B1
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This is a copy of an article published in Antioxidants and Redox Signalling ©2011 copyright Mary Ann Liebert, Inc.; Antioxidants and Redox Signalling is available online at: Online Ahead of Print: October 28, 2010. Online Ahead of Editing: September 20, 2010. Published under "Forum Editorial".

Document type: Journal Article
Sub-type: Editorial
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Sun, 12 Dec 2010, 00:12:46 EST