Abortive keratoacanthoma: A hitherto unrecognised variant

Weedon, David, Brooks, David, Malo, Jonathan and Williamson, Richard (2010) Abortive keratoacanthoma: A hitherto unrecognised variant. Pathology, 42 7: 661-663.


Author Weedon, David
Brooks, David
Malo, Jonathan
Williamson, Richard
Title Abortive keratoacanthoma: A hitherto unrecognised variant
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
1465-3931
Publication date 2010-12
Sub-type Article (original research)
DOI 10.3109/00313025.2010.522176
Volume 42
Issue 7
Start page 661
End page 663
Total pages 3
Place of publication London , U. K.
Publisher Wolters Kluwer
Collection year 2011
Language eng
Formatted abstract Aims: To study the histological features of abortive keratoacanthoma, a variant that has only recently been recognised.

Methods: A key word search of the database of our pathology practice was carried out for all keratoacanthomas (KAs) reported by one author (DW) over a 14-month period. These cases were then sorted into histological subtypes by age in decades.

Results: A total of 3465 cases of KA were reported over this period, of which 582 (16.8%) were of the so-called abortive type. Abortive KAs are characterised by rapid growth and subsequent lichenoid regression at an early stage in their evolution. Lichenoid changes extend for a variable distance beyond the lesion.

Conclusions: Abortive KA is a hitherto unrecognised variant of KA which may be misdiagnosed as squamous cell carcinoma despite its distinctive features. Lichenoid regression, rather than terminal differentiation, is the main mechanism of its involution.
Keyword Keratoacanthoma
Regression
Lichenoid change
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 12 Dec 2010, 00:01:45 EST