Effects of anti-diuretic hormone on urine flow and composition in chronically-cannulated ovine fetus

Lingwood, Barbara, Hardy, K.J., Horacek, I., McPhee, M.L., Scoggins, B.A. and Wintour, E. Marelyn (1978) Effects of anti-diuretic hormone on urine flow and composition in chronically-cannulated ovine fetus. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 63 4: 315-330.

Author Lingwood, Barbara
Hardy, K.J.
Horacek, I.
McPhee, M.L.
Scoggins, B.A.
Wintour, E. Marelyn
Title Effects of anti-diuretic hormone on urine flow and composition in chronically-cannulated ovine fetus
Journal name Quarterly Journal of Experimental Physiology and Cognate Medical Sciences   Check publisher's open access policy
ISSN 0033-5541
Publication date 1978
Sub-type Article (original research)
Volume 63
Issue 4
Start page 315
End page 330
Total pages 16
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The fetuses of nine pregnant ewes were chronically cannulated between 86 and 130 days with cannulae in one carotid artery, one jugular vein, the fetal bladder and the amniotic cavity. The effects of infused AVP on fetal urine flow rate and composition were studied. A dose of 35 pmol . h-' always caused an increase in urine osmolality and a decrease in flow rate and free water clearance without change in blood pressure. Higher doses (140 pmol.h-1) weresignificantly pressor and caused increased excretion of sodium, chloride, urea and creatinine. Although this dose always caused an increase in urine osmolality, in five experiments the flow rate also rose. It is concluded that the ovine fetus has the ability to control its own urine flow and composition, and possibly also amniotic fluid volume and composition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Tue, 07 Dec 2010, 09:33:54 EST