No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients

Middle, Fiona, Pritchard, Antonia L., Handoko, Herlina, Haque, Sayeed, Holder, Roger, Bentham, Peter and Lendon, Corinne L. (2010) No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients. Journal of Alzheimer's Disease, 20 2: 561-567. doi:10.3233/JAD-2010-1405

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Author Middle, Fiona
Pritchard, Antonia L.
Handoko, Herlina
Haque, Sayeed
Holder, Roger
Bentham, Peter
Lendon, Corinne L.
Title No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients
Journal name Journal of Alzheimer's Disease   Check publisher's open access policy
ISSN 1387-2877
1875-8908
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.3233/JAD-2010-1405
Volume 20
Issue 2
Start page 561
End page 567
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher IOS Press
Collection year 2011
Language eng
Abstract Alzheimer's disease (AD) patients commonly suffer from behavioral and psychological symptoms of dementia (BPSD). Variants within the neuregulin-1 (NRG1) gene have been investigated both in early onset psychiatric disorders, such as schizophrenia and recently in AD patients with psychosis. In this study, we analyzed NRG1 variants in AD patients with and without psychosis. Our large cohort of 399 probable AD patients had longitudinal information on the BPSD, which was used to dichotomize patients into whether they had ever suffered from psychotic symptoms within the study period. The NRG1 single nucleotide polymorphisms rs3924999, rs35753505 (SNP8NRG221533) and the microsatellites 478B14-848 and 420M9-1395 were investigated for association with psychosis using genotype, allele, and haplotype analyses. No associations were found between any of these variants or haplotypic combinations with delusions, hallucinations, psychosis, or elation/mania in our cohort. Positive associations with polymorphisms and haplotype combinations of NRG1 have been reported in psychiatric disorders. One previous study found an association with psychosis in AD, with a SNP outside the haplotype block first reported for association with schizophrenia. We found no association with any of these variants in our cohort. Further investigations of this region on chromosome 8 are clearly required, with replication in different large longitudinal cohorts. © 2010 - IOS Press and the authors. All rights reserved.
Keyword Alzheimer's disease
BPSD
Haplotype
Neuregulin 1
Psychosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Mon, 06 Dec 2010, 15:42:52 EST by Lisa Hennell on behalf of Medicine - Royal Brisbane and Women's Hospital