Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment

Ashauer, Roman and Escher, Beate I. (2010) Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment. Journal of Environmental Monitoring, 12 11: 2056-2061.


Author Ashauer, Roman
Escher, Beate I.
Title Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment
Journal name Journal of Environmental Monitoring  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2010-11
Sub-type Article
DOI 10.1039/c0em00234h
Volume number 12
Issue number 11
ISSN 1464-0325; 1464-0333
Start page 2056
End page 2061
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2011
Language eng
Abstract Toxicokinetic-toxicodynamic (TK-TD) models simulate the processes that lead to toxicity at the level of organisms over time. These dynamic simulation models quantify toxicity, but more importantly they also provide a conceptual framework to better understand the causes for variability in different species' sensitivity to the same compound as well as causes for different toxicity of different compounds to the same species. Thus TK-TD models bring advantages for very diverse ecotoxicological questions as they can address two major challenges: the large number of species that are potentially affected and the large number of chemicals of concern. The first important benefit of TK-TD models is the role that they can play to formalize established knowledge about toxicity of compounds, sensitivity of organisms, organism recovery times and carry-over toxicity. The second important aspect of TK-TD models is their ability to simulate temporal aspects of toxicity which makes them excellent extrapolation tools for risk assessment of fluctuating or pulsed exposures to pollutants. We provide a general introduction to the concept of TK-TD modelling for environmental scientists and discuss opportunities as well as current limitations. © 2010 The Royal Society of Chemistry.
Keyword Time-dependent toxicity
Damage assessment model
Lethal body residues
Dose-effect model
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collections: Official 2011 Collection
National Research Centre for Environmental Toxicology Publications
 
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Created: Sun, 05 Dec 2010, 00:08:26 EST