Effects of a gliadin-combined plant superoxide dismutase extract on self-perceived fatigue in women aged 50-65 years

Houghton, C. A., Steels, E. L., Fassett, R. G. and Coombes, J. S. (2011) Effects of a gliadin-combined plant superoxide dismutase extract on self-perceived fatigue in women aged 50-65 years. Phytomedicine, 18 6: 521-526. doi:10.1016/j.phymed.2010.09.006

Author Houghton, C. A.
Steels, E. L.
Fassett, R. G.
Coombes, J. S.
Title Effects of a gliadin-combined plant superoxide dismutase extract on self-perceived fatigue in women aged 50-65 years
Journal name Phytomedicine   Check publisher's open access policy
ISSN 0944-7113
Publication date 2011-04-15
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.phymed.2010.09.006
Volume 18
Issue 6
Start page 521
End page 526
Total pages 6
Place of publication Jena, Germany
Publisher Urban und Fischer Verlag
Collection year 2011
Language eng
Formatted abstract
Fatigue syndromes exist on a continuum of severity from mild and transient to the disabling chronic fatigue syndrome, with oxidative stress linked to its pathogenesis. A thermolabile gliadin-combined plant superoxide dismutase (SOD) extract has shown potential in clinical trials as a therapeutic antioxidant. This study investigated the effects of 12 weeks of 500 mg/day of a SOD/gliadin supplement on fatigue. Thirty-eight women aged 50-65 years with self-perceived fatigue entered this randomized, double-blind, placebo-controlled trial. The primary outcome measure was general fatigue determined by the Multidimensional Fatigue Inventory (MFI). Secondary outcome measures included other measures of fatigue from the MFI and blood measures of oxidative stress, antioxidant status and hormones. There were no significant (P > 0.05) differences between, or within groups, for decreases in general fatigue (active = 1.6%, placebo = 4.1%). There were no within or between group differences (P > 0.05) in other measures of fatigue (physical fatigue, reduced activity, reduced motivation, mental fatigue and total fatigue score). In regard to the biochemical measures, there were non-significant (P > 0.05) differences in increases in plasma SOD activity (active = 7.1%, placebo = 12.2%), plasma GPx activity (active = 2.4%, placebo = 0.7%), red blood cell GPx activity (active = 9.8%, placebo = 4.4%). Markers of oxidative stress were decreased but there were no differences (P > 0.05) within or between groups; malondialdehyde (active = 4.1%, placebo = 1.6%), F-2 isoprostanes (active = 14.7%, placebo = 22.4%). There was a trend (P = 0.08) for a decrease in cortisol in the active group (24.6%), however this was not significantly different from the decrease in the placebo participants (4.1%). DHEA differences were not significant (P < 0.05) and declined 1.3% in the active group and 14.4% in the placebo group. In summary, the thermolabile SOD/gliadin supplement had no significant effect on self-perceived fatigue, antioxidants, oxidative stress or hormones in women aged 50-65 years.
© 2010 Elsevier GmbH. All rights reserved.
Keyword Antioxidants
Double blind
Oxidative stress
Placebo controlled trial
Thermolabile enzymes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 1 November 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 03 Dec 2010, 09:31:36 EST by Professor Robert Fassett on behalf of School of Human Movement and Nutrition Sciences