Formulation and physical characterization of microemulsions containing isotretinoin

Ramli, S, Ross, BP and Gentle, IR (2009). Formulation and physical characterization of microemulsions containing isotretinoin. In: ICBPE 2009 : 2nd International Conference on Biomedical and Pharmaceutical Engineering: Conference proceedings. International Conference on Biomedical and Pharmaceutical Engineering, Singapore, Republic of Singapore, (129-135). 2-4 December 2009. doi:10.1109/ICBPE.2009.5384088


Author Ramli, S
Ross, BP
Gentle, IR
Title of paper Formulation and physical characterization of microemulsions containing isotretinoin
Conference name International Conference on Biomedical and Pharmaceutical Engineering
Conference location Singapore, Republic of Singapore
Conference dates 2-4 December 2009
Proceedings title ICBPE 2009 : 2nd International Conference on Biomedical and Pharmaceutical Engineering: Conference proceedings
Journal name 2009 International Conference On Biomedical and Pharmaceutical Engineering
Place of Publication Piscataway, N.J, U.S.A.
Publisher IEEE - Institute for Electrical and Electronic Engineers
Publication Year 2009
Sub-type Fully published paper
DOI 10.1109/ICBPE.2009.5384088
ISBN 9781424447633
Start page 129
End page 135
Total pages 6
Language eng
Formatted Abstract/Summary
Physical properties of microemulsions containing tween80 as surfactant and tetraglycol as cosurfactant, were investigated for their potential to form microemulsion templates as drug delivery vehicles for isotretinoin. Bile salt was used as edge activator in skin permeation and surfactant protein B (SP-B1-25) may be helpful in drug delivery and reducing sebum level. All of the compounds used to formulate the microemulsions were pharmaceutically acceptable and biocompatible. The drug-containing systems were characterized in regard to their transdermal parameters. Physiologically well-tolerated and physically stable multiple-component systems were developed. The concentrations of surfactants and cosurfactants which are necessary to form stable systems were evaluated. Microemulsions were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), electric conductivity and rheometry. The influence of isotretinoin on the physical parameters of the preparation was investigated.
©2009 Crown

Keyword Microemulsion
Isotretinoin
Stability
Electrical conductivity
Viscosity
Drug-delivery systems
Conductivity
Acne
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Sun, 28 Nov 2010, 00:08:55 EST