Association of 5HTTLPR, personality traits and alcohol craving in alcohol-dependent subjects

Ho, A. M. -C., Daglish, M. R., Dodd, P. R. and Stadlin, A. (2010). Association of 5HTTLPR, personality traits and alcohol craving in alcohol-dependent subjects. In: Abstracts of the 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry. 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry, Phuket, Thailand, (78-79). 18-20 October 2010. doi:10.1111/j.1471-4159.2010.06944.x


Author Ho, A. M. -C.
Daglish, M. R.
Dodd, P. R.
Stadlin, A.
Title of paper Association of 5HTTLPR, personality traits and alcohol craving in alcohol-dependent subjects
Conference name 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry
Conference location Phuket, Thailand
Conference dates 18-20 October 2010
Proceedings title Abstracts of the 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry   Check publisher's open access policy
Journal name Journal of Neurochemistry   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Wiley-Blackwell Publishing
Publication Year 2010
Year available 2010
Sub-type Published abstract
DOI 10.1111/j.1471-4159.2010.06944.x
ISSN 0022-3042
1471-4159
Volume 115
Issue Supp. 1
Start page 78
End page 79
Total pages 2
Language eng
Formatted Abstract/Summary
Stress response and personality play important roles in cravinginduced relapse. Both of these factors are under high genetic influences. Serotonin transporter-linked promoter region (5HTTLPR) is one of the candidate polymorphisms that have been associated with affective disorders and personality. The aim of this study is to investigate the correlations among alcohol craving, personality traits and salivary cortisol level, and the association between 5HTTLPR and these factors. Eighty-seven alcohol-dependent subjects were recruited during a 5-day detoxification treatment. Neuroticism, extraversion and conscientiousness were measured by NEO PI-R. Global alcohol craving level of the week prior to admission was measured by Obsessive Compulsive Drinking Scale; while state alcohol craving level was measured by Alcohol Urge Questionnaire in a morning of day 3–day 5, and a saliva sample was collected subsequently for cortisol measurement. We observed that
global alcohol craving prior to treatment was correlated with neuroticism (Spearman’s rho = 0.264, p = 0.021); while state alcohol craving during late stage of detoxification treatment was correlated with conscientiousness (Spearman’s rho = -0.227, p = 0.040) and salivary cortisol level (Spearman’s rho = 0.366; p = 0.010). 5HTTLPR short-allele carriers scored significantly higher in conscientiousness than non-allele carriers after controlling for subjects' age (p = 0.031). Although we did not observed significant association between 5HTTLPR alcohol craving, the influence of 5HTTLPR may be imposed indirectly through conscientious personality traits: short allele is associated with higher conscientiousness.
© 2010 The Authors. Journal compilation © 2010 International Society for Neurochemistry
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: Abstracts of the 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry. Abstract number WE04-11.

 
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Created: Sun, 28 Nov 2010, 00:03:02 EST