Effects of streptozotocin-induced diabetes on neural sigma receptors in the rat brain

Mardon, Karine, Kassiou, Michael and Donald, Angela (1999) Effects of streptozotocin-induced diabetes on neural sigma receptors in the rat brain. Life Sciences, 65 23: PL-281-PL-286.


Author Mardon, Karine
Kassiou, Michael
Donald, Angela
Title Effects of streptozotocin-induced diabetes on neural sigma receptors in the rat brain
Journal name Life Sciences
Publication date 1999-10-29
Sub-type Article
DOI 10.1016/S0024-3205(99)00521-4
Volume number 65
Issue number 23
ISSN 0024-3205; 1879-0631
Start page PL-281
End page PL-286
Total pages 6
Place of publication Philadelphia, PA, U.S.A.
Publisher Elsevier
Formatted abstract To study the effect of diabetes mellitus on the density of a receptors, in vitro binding experiments were conducted in whole brain homogenate membranes of 5-week and 10-week control rats and streptozotocin (STZ)-induced diabetic rats, σ-1 Receptors were labelled with [3H](+)-pentazocine while σ-2 receptors were labelled with [3H]1,3-di-o-tolylguanidine (DIG) in the presence of 0.5 μM (+)-pentazocine to mask σ-1 sites. Non-specific binding was determined in the presence of 20 μM haloperidol. Scatchard analysis revealed a 27% (p < 0.01) decreased in σ-1 receptor density and a 33% (p < 0.01) decreased in σ-2 receptor density in whole brain of 10-week STZ-diabetic rats. No statistically significant difference was found in the σ receptor content of 5-week STZ-diabetic rats. These results provide evidence that neuronal σ receptors are reduced in 10-week STZ-diabetic rats and suggest that changes in α receptors may play a role in diabetes related abnormalities. Further evaluation is required to determine whether changes observed in the brain are homogeneous for either or both σ receptor subtypes as well as potential links between other CNS receptor changes previously observed in STZ-induced diabetic rats.
Copyright © 1999 Published by Elsevier Science Inc.
Keyword Diabetes
Streptozotocin
Sigma receptors
CNS
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collection: Centre for Advanced Imaging Publications
 
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Created: Fri, 26 Nov 2010, 15:25:58 EST by Dr Karine Mardon on behalf of Centre for Advanced Imaging