Alterations of myocardial sympathetic innervation in response to hypoxia

Scherrer-Crosbie, Marielle, Mardon, Karine, Cayla, Jerome, Syrota, Andre and Merlet, Pascal (1997) Alterations of myocardial sympathetic innervation in response to hypoxia. Journal of Nuclear Medicine, 38 6: 954-957.


Author Scherrer-Crosbie, Marielle
Mardon, Karine
Cayla, Jerome
Syrota, Andre
Merlet, Pascal
Title Alterations of myocardial sympathetic innervation in response to hypoxia
Journal name Journal of Nuclear Medicine
ISSN 0161-5505
0022-3123
0097-9031
Publication date 1997-06
Sub-type Article (original research)
Volume 38
Issue 6
Start page 954
End page 957
Total pages 4
Place of publication Chicago, Ill. U.S.A
Publisher Society of Nuclear Medicine
Language eng
Formatted abstract The effects of altitude hypoxia on myocardial sympathetic nerve function were assessed in rats using metaiodobenzylguanidine (MIBG).

Methods:
To estimate the change in uptake-1 function induced by hypoxia, three sets of rats were submitted to 5-, 7- and 21-day hypoxia (hypobaric chamber at 410 Torr) and one set of control rats was injected with 25 μCi of 123I-MIBG. Four hours later, the rats were killed and 123I activity was counted in both ventricles. The proportion of MIBG fixed in the myocardium through the norepinephrine (NE) transporter (uptake-1) was evaluated indirectly in 5-day hypoxic and controls rats by the injection of desipramine before 123I- MIBG administration. Myocardial perfusion was evaluated in 5-day hypoxic rats and controls by 201Tl injection.

Results:
Myocardial 123I-MIBG activity was 0.253% ± 0.036% kg dose/g-1 in controls and was decreased (0.188% ± 0.029% kg dose/g p =0.001) in 5-day hypoxic rats. This decrease was not related to a change in cardiac perfusion. The decrease in MIBG uptake existed before the appearance of cardiac hypertrophy. Desipramine de creased MIBG uptake by 48% in controls and 17% in hypoxic rats, suggesting that the decrease predominantly affected MIBG uptake by the NE transporter.

Conclusion:
Chronic hypoxia leads to a decrease in myocardial NE uptake-1 function. This finding suggests that altered tissue oxygen supply could play a role in the decreased cardiac MIBG uptake reported in human cardiomyopathies.
Keyword Desipramine
Hypoxia
Iodine-123-metaiodobenzylguanidine
Uptake-1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Fri, 26 Nov 2010, 13:52:39 EST by Dr Karine Mardon on behalf of Centre for Advanced Imaging