Bromine-76-Metabromobenzylguanidine: A PET Radiotracer for Mapping Sympathetic Nerves of the Heart

Héric Valette, Christian Loc'h, Karine Mardon, Bernard Bendriem, Pascal Merlet, Chantal Fuseau, Sana Sabry, David Raffel, Bernard Mazière and André Syrota (1993) Bromine-76-Metabromobenzylguanidine: A PET Radiotracer for Mapping Sympathetic Nerves of the Heart. Journal of Nuclear Medicine, 34 10: 1739-1744.


Author Héric Valette
Christian Loc'h
Karine Mardon
Bernard Bendriem
Pascal Merlet
Chantal Fuseau
Sana Sabry
David Raffel
Bernard Mazière
André Syrota
Title Bromine-76-Metabromobenzylguanidine: A PET Radiotracer for Mapping Sympathetic Nerves of the Heart
Journal name Journal of Nuclear Medicine   Check publisher's open access policy
ISSN 0161-5505
1535-5667
Publication date 1993-10-01
Sub-type Article (original research)
Volume 34
Issue 10
Start page 1739
End page 1744
Total pages 6
Place of publication Reston, VA, United States
Publisher Society of Nuclear Medicine
Language eng
Abstract Iodine-123-metaiodobenzylguanidine (MIBG) is used to qualitatively assess heart innervation with single-photon emission computed tomography (SPECT). This approach is clinically useful in the prognostic evaluation of congestive heart failure. To improve quantification of uptake of the tracer using positron emission tomography (PET), we studied the characteristics of the bromoanalog of MIBG. Bromine-76-metabromobenzylguanidine (76Br-MBBG) was prepared from a heteroisotopic exchange between radioactive bromine atoms (noncarrier-added (76Br) BrNH4) and the cold iodine atoms of the precursor metaiodobenzylguanidine. Biodistribution was studied in rats and PET cardiac imaging performed in dogs. Myocardial uptake was high and prolonged in both species (mean half-life in dogs: 580 min). In rats, myocardial uptake was inhibited by desipramine by 64%, whereas after pretreatment with 6- hydroxydopamine uptake was reduced by 84%. In dogs pretreated with 6- hydroxydopamine or with desipramine, a steep washout of the tracer occurred (mean half-life: 136 min and 118 min, respectively). The non-specific uptake plus the passive neuronal diffusion of the tracer could be estimated at about 25%-30% of the total fixation. In dogs, analysis of unchanged 76Br-MBBG in plasma showed that radiotracer metabolism was slow: 60 min after injection, 80% of the radioactivity was related to unchanged 76Br-MBBG. These preliminary findings suggest that 76Br-MBBG could be used to quantitatively assess adrenergic innervation in heart disease using PET. When combined with use of 11C-CGP 12177, cardiac adrenergic neurotransmission can be assessed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Fri, 26 Nov 2010, 12:12:55 EST by Dr Karine Mardon on behalf of Centre for Advanced Imaging