Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase: IoxP system

Wallace, Daniel F., Tonks, Ian D., Zournazi, Anna, Kay, Graham F. and Subramaniam, V. Nathan (2004) Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase: IoxP system. Genesis, 39 1: 38-41. doi:10.1002/gene.20023


Author Wallace, Daniel F.
Tonks, Ian D.
Zournazi, Anna
Kay, Graham F.
Subramaniam, V. Nathan
Title Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase: IoxP system
Formatted title
Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase: IoxP system
Journal name Genesis   Check publisher's open access policy
ISSN 1526-954X
1526-968X
Publication date 2004-05-01
Sub-type Article (original research)
DOI 10.1002/gene.20023
Volume 39
Issue 1
Start page 38
End page 41
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre-recombinase: loxP system used to create the mice allows both full deletion and tissue-specific deletion of TfR2. The development of these mice will provide new models for type 3 hemochromatosis and assist in determining the role of TfR2 in iron metabolism.
Keyword Transferrin receptor 2
Conditional knockout
Hemochromatosis
Iron homeostasis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 25 Nov 2010, 20:33:55 EST