Effect of surgery on normal tissue toxicity in patients treated with accelerated radiotherapy

Wratten, Christopher R., Poulsen, Michael G., Williamson, Steve, Tripcony, Lee, Keller, Jacqui and Dickie, Graeme (2002) Effect of surgery on normal tissue toxicity in patients treated with accelerated radiotherapy. Acta Oncologica, 41 1: 56-62. doi:10.1080/028418602317314073


Author Wratten, Christopher R.
Poulsen, Michael G.
Williamson, Steve
Tripcony, Lee
Keller, Jacqui
Dickie, Graeme
Title Effect of surgery on normal tissue toxicity in patients treated with accelerated radiotherapy
Journal name Acta Oncologica   Check publisher's open access policy
ISSN 0284-186X
1651-226X
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1080/028418602317314073
Volume 41
Issue 1
Start page 56
End page 62
Total pages 7
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Abstract The aim of this study was to assess the effect of surgery on normal tissue toxicity in head and neck cancer patients treated with accelerated radiotherapy. Toxicity data from two trials of accelerated radiotherapy were compared. The first group was taken from a phase III trial of definitive radiotherapy and the second group from a phase II trial of postoperative radiotherapy. The general eligibility criteria (apart from surgery), data collection and radiotherapy details for both trials were similar. The definitive group included 172 eligible patients and the postoperative group 52 eligible patients. At 3 weeks into treatment, by which time the dose and rate of dose accumulation were identical, there was no difference in acute toxicity. Analysis of late toxicity showed greater subcutaneous fibrosis in the postoperative group.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 24 Nov 2010, 00:51:38 EST