Triple therapy for advanced squamous cell cancer of the head and neck

Smith, I.M., Poulsen, M., Jackson, M., Thomson, D. and Coman, W.B. (1992) Triple therapy for advanced squamous cell cancer of the head and neck. Australian and New Zealand Journal of Surgery, 62 5: 373-381. doi:10.1111/j.1445-2197.1992.tb07206.x

Author Smith, I.M.
Poulsen, M.
Jackson, M.
Thomson, D.
Coman, W.B.
Title Triple therapy for advanced squamous cell cancer of the head and neck
Journal name Australian and New Zealand Journal of Surgery   Check publisher's open access policy
ISSN 0004-8682
Publication date 1992-05
Sub-type Article (original research)
DOI 10.1111/j.1445-2197.1992.tb07206.x
Volume 62
Issue 5
Start page 373
End page 381
Total pages 9
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing
Language eng
Abstract This study presents the results of treatment for Stage III and IV squamous cell carcinoma of the head and neck at the Princess Alexandra Hospital and Queensland Radium Institute, Brisbane. Patients were treated using a programme of sequential chemotherapy, surgery and radiotherapy. Between 1980 and 1988, 116 patients commenced the programme and 85 completed the treatment as planned. The Price-Hill regimen of chemotherapy was used until 1986 after which time it was replaced by cisplatin/5-fluorouracil (5FU). Two courses were usually given achieving an overall response rate of 36% (12% complete response). Cisplatin/5FU produced an overall response rate of 56% compared with 24% for the Price-Hill regimen. Radical surgical resections were performed using a free flap reconstruction in the majority of patients. Radiotherapy fields usually covered the primary site and both cervical lymph node areas to a dose of 50–60 Gy in 5–6 weeks. The lengthy treatment was generally well tolerated although there were two chemotherapy and two peri-operative deaths. The overall actuarial survival for the 85 patients completing the triple therapy was 60%. These patients were analysed in more detail for possible prognostic factors.
Keyword Chemotherapy
Free flap reconstruction
Head and neck cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 21 January 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 23 Nov 2010, 14:51:24 EST