Treatment decisions in T3N0M0 glottic carcinoma

Bryant, Guy P., Poulsen, Michael G., Tripcony, Lee and Dickie, Graeme J. (1995) Treatment decisions in T3N0M0 glottic carcinoma. International Journal of Radiation Oncology Biology Physics, 31 2: 285-293. doi:10.1016/0360-3016(94)E0172-G

Author Bryant, Guy P.
Poulsen, Michael G.
Tripcony, Lee
Dickie, Graeme J.
Title Treatment decisions in T3N0M0 glottic carcinoma
Journal name International Journal of Radiation Oncology Biology Physics   Check publisher's open access policy
ISSN 0360-3016
Publication date 1995-01
Sub-type Article (original research)
DOI 10.1016/0360-3016(94)E0172-G
Volume 31
Issue 2
Start page 285
End page 293
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
To analyze the results of T3N0M0 glottic carcinoma treated with radiotherapy, surgery, or both.

Methods and Materials:
The records were retrospectively reviewed of 97 patients with this tumor subsite and stage seen for treatment at the Queensland Radium Institute over a 29-year period. The results for radiotherapy with surgical salvage of failure (XRT/SS) were compared to those with surgery with or without radiotherapy (SURG/SURG+XRT). For those treated initially with radiotherapy alone, the results for different ranges of biologically equivalent doses were compared. These results were compared to those of other published studies.

The 5- year disease-specific survival rates for the XRT/SS and SURG/SURG+XRT groups were 50% and 58%, respectively; this difference is not significant. For the XRT/SS group, there was a trend towards improved 5-year recurrence-free survival (73%) and 5-year disease-specific survival (86%) in those treated to a dose equivalent to 60-64 Gy in 2 Gy fractions, when compared with higher or lower dose equivalents.

A group of patients with T3N0M0 glottic carcinoma is specified for which the option of radiotherapy offers a similar chance of survival to those treated surgically. More than 50% of the XRT/SS survivors will retain their larynx.
Keyword Glottis carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 23 Nov 2010, 14:45:27 EST