Fetal stem cell microchimerism: natural-born healers or killers?

Lee, Eddy S. M., Bou-Gharios, George, Seppanen, Elke, Khosrotehrani, Kiarash and Fisk, Nicholas M. (2010) Fetal stem cell microchimerism: natural-born healers or killers?. Molecular Human Reproduction, 16 11: 869-878. doi:10.1093/molehr/gaq067

Author Lee, Eddy S. M.
Bou-Gharios, George
Seppanen, Elke
Khosrotehrani, Kiarash
Fisk, Nicholas M.
Title Fetal stem cell microchimerism: natural-born healers or killers?
Journal name Molecular Human Reproduction   Check publisher's open access policy
ISSN 1360-9947
Publication date 2010-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/molehr/gaq067
Volume 16
Issue 11
Start page 869
End page 878
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2011
Language eng
Abstract After four decades of study, the biological role of fetal microchimerism (FMC) remains elusive. Transfer of fetal cells to the mother begins soon after implantation, and increases with gestational age. FMC cells then decline after delivery, but remain detectable for years post-partum. These cells have been implicated in rheumatoid arthritis remission during pregnancy and the prevention of breast cancer by graft-versus-tumor-effects. However, any beneficial effects contrast with their suspected malevolence in triggering of systemic sclerosis after childrearing or their stromal support for tumor formation. Recent evidence that FMC cells participate in disease and tissue repair has stirred controversy on their origin. The detection of FMC cells during early embryogenesis together with the diversity of hematopoietic, mesenchymal and endothelial markers, and plasticity of morphology when integrated into various tissues, provides evidence for their stemness. However, proof of their phenotype in conventional stem cell differentiation assays has been beset with difficulty in isolating and expanding them in culture. Unraveling the function of FMC cells will provide insight into both their engagement in disease and their therapeutic potential. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Keyword Stem cell trafficking
Fetomaternal hemorrhage
Tissue repair
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
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Created: Sun, 21 Nov 2010, 00:01:42 EST