Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection

Zosky, Graeme R., Cannizzaro, Vincenzo, Hantos, Zoltan and Sly, Peter D. (2009) Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection. Journal of Applied Physiology, 107 5: 1472-1478. doi:10.1152/japplphysiol.00393.2009


Author Zosky, Graeme R.
Cannizzaro, Vincenzo
Hantos, Zoltan
Sly, Peter D.
Title Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
1522-1601
Publication date 2009-11
Sub-type Article (original research)
DOI 10.1152/japplphysiol.00393.2009
Volume 107
Issue 5
Start page 1472
End page 1478
Total pages 7
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract The degree to which mechanical ventilation induces ventilator-associated lung injury is dependent on the initial acute lung injury (ALI). Viral-induced ALI is poorly studied, and this study aimed to determine whether ALI induced by a clinically relevant infection is exacerbated by protective mechanical ventilation. Adult female BALB/c mice were inoculated with 104.5 plaque-forming units of influenza A/Mem/1/71 in 50 μl of medium or medium alone. This study used a protective ventilation strategy, whereby mice were anesthetized, tracheostomized, and mechanically ventilated for 2 h. Lung mechanics were measured periodically throughout the ventilation period using a modification of the forced oscillation technique to obtain measures of airway resistance and coefficients of tissue damping and tissue elastance. Thoracic gas volume was measured and used to obtain specific airway resistance, tissue damping, and tissue elastance. At the end of the ventilation period, a bronchoalveolar lavage sample was collected to measure inflammatory cells, macrophage inflammatory protein-2, IL-6, TNF-α, and protein leak. Influenza infection caused significant increases in inflammatory cells, protein leak, and deterioration in lung mechanics that were not exacerbated by mechanical ventilation, in contrast to previous studies using bacterial and mouse-specific viral infection. This study highlighted the importance of type and severity of lung injury in determining outcome following mechanical ventilation.
Keyword ventilator-associated lung injury
viral infection
BALB/c
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:59:34 EST