A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research

Yeatts, Karin, Sly, Peter, Shore, Stephanie, Weiss, Scott, Martinez, Fernando, Geller, Andrew, Bromberg, Philip, Enright, Paul, Koren, Hillel, Weissman, David and Selgrade, MaryJane (2006) A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research. Environmental Health Perspectives, 114 4: 634-640. doi:10.1289/ehp.8381


Author Yeatts, Karin
Sly, Peter
Shore, Stephanie
Weiss, Scott
Martinez, Fernando
Geller, Andrew
Bromberg, Philip
Enright, Paul
Koren, Hillel
Weissman, David
Selgrade, MaryJane
Title A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research
Journal name Environmental Health Perspectives   Check publisher's open access policy
ISSN 0091-6765
1552-9924
Publication date 2006-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1289/ehp.8381
Volume 114
Issue 4
Start page 634
End page 640
Total pages 7
Place of publication Research Triangle Park, NC, United States
Publisher U.S. Department of Health and Human Services
Language eng
Abstract Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies for the prevention of asthma. The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences held a conference in October 2004 to collaboratively discuss a future research agenda in this area. The first three articles in this mini-monograph summarize the discussion on potential putative environmental exposure; they include an overview of asthma and conclusions of the workshop participants with respect to public health actions that could currently be applied to the problem and research needs to better understand and control the induction and incidence of asthma, the potential role of indoor/outdoor air pollutants in the induction of asthma), and biologics in the induction of asthma. Susceptibility is a key concept in the U.S. EPA “Asthma Research Strategy” document and is associated with the U.S. EPA framework of protecting vulnerable populations from potentially harmful environmental exposures. Genetics, age, and lifestyle (obesity, diet) are major susceptibility factors in the induction of asthma and can interact with environmental exposures either synergistically or antagonistically. Therefore, in this fourth and last article we consider a number of “susceptibility factors” that potentially influence the asthmatic response to environmental exposures and propose a framework for developing research hypotheses regarding the effects of environmental exposures on asthma incidence and induction.
Keyword Asthma
Epidemiology
Genetics
Hygiene hypothesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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